Marie Louise of Orléans (26 March 1662 – 12 February 1689) was Queen consort of Spain from 1679 to 1689 as the first wife of King Charles II of Spain. She was a granddaughter of Louis XIII of France. In her adopted country, she was known as María Luisa de Orléans. Marie Louise d'Orléans was born at the Palais Royal in Paris. She was the eldest daughter of Philippe, Duke of Orléans, the younger brother of Louis XIV of France and of his first wife, Henrietta Anne of England. As a petite-fille de France she was entitled to the attribute of Royal Highness, although, as was customary at court at the palace of Versailles, her style, Mademoiselle d'Orléans, was more often used. On 19 November 1679, Marie Louise married Charles II in person in Quintanapalla, near Burgos, Spain. This was the start of a lonely existence at the Spanish court. Her new husband had fallen in love with her and remained so until the end of his life.

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