Isabella of Portugal (Spanish: Isabel; English: Elizabeth; 24 October 1503 – 1 May 1539) was a Holy Roman Empress and Queen of Spain, Germany, Italy, Naples and Sicily and Duchess of Burgundy by her marriage to Holy Roman Emperor Charles V, and regent of Spain during the absences of her husband during 1529-1532, 1535-1536 and 1538-1539. Isabella was the granddaughter of the Catholic Monarchs, Isabella I of Castile and Fernando II of Aragon. Throughout her life, many would compare her to her grandmother for her character and her determination in politics. A woman of great beauty and intelligence, Isabella was undoubtedly the Spanish soul of Charles V who, because of his travels in Europe, spent little time in Spain due to political affairs abroad. It was thanks to the governorships of Empress Isabella that Spain was able to remain independent of imperial policies. Isabella was the second child and eldest daughter of King Manuel I of Portugal and his second wife Maria of Aragon.

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